• Schematic of one step in the protein translocation mechanism of Vps4

    Schematic of one step in the protein translocation mechanism of Vps4 | View Abstract

  • cryoEM structure of the AAA ATPase VPS4 in complex with an ESCRT-III substrate

    cryoEM structure of the AAA ATPase VPS4 in complex with an ESCRT-III substrate | View Abstract

  • Superposition of the structures of the ALIX Bro1 domain (gray) bound to the tail of wild type (green) and the cancer susceptibility allele of CHMP4C

    Superposition of the structures of the ALIX Bro1 domain (gray) bound to the tail of wild type (green) and the cancer susceptibility allele of CHMP4C | View Abstract

  • Structure (left) and anti-HIV-1 potency of the Gilead capsid inhibitor, GS-CA1

    Structure (left) and anti-HIV-1 potency of the Gilead capsid inhibitor, GS-CA1 | View Abstract

  • Cryo-EM structures showing how the ESCRT-III protein CHMP1B tubulates membranes (left) and how addition of IST1 constricts the membrane further (right)

    Cryo-EM structures showing how the ESCRT-III protein CHMP1B tubulates membranes (left) and how addition of IST1 constricts the membrane further (right) | View Abstract

  • Graphic showing the remarkable longevity of the Gilead HIV-1 capsid inhibitor GS-6207 (Lenacapavir) in humans

    Graphic showing the remarkable longevity of the Gilead HIV-1 capsid inhibitor GS-6207 (Lenacapavir) in humans | View Abstract

  • Summary of the steps in reconstituting efficient HIV-1 endogenous reverse transcription and integration in vitro

    Summary of the steps in reconstituting efficient HIV-1 endogenous reverse transcription and integration in vitro | View Abstract

  • Structure of the high affinity complex between the first PPxY element of the HIV-1 budding factor AMOT and the third WW domain of the NEDD4L ubiquitin ligase (silver)

    Structure of the high affinity complex between the first PPxY element of the HIV-1 budding factor AMOT and the third WW domain of the NEDD4L ubiquitin ligase (silver)
    View Abstract

  • Cell cycle showing the formation of a novel cytoplasmic organelle, the abscission checkpoint body (green), at the late midbody stage in cells with active abscission checkpoints (lower row) but not in cells with satisfied abscission checkpoints (upper

    Cell cycle showing the formation of a novel cytoplasmic organelle, the abscission checkpoint body (green), at the late midbody stage in cells with active abscission checkpoints (lower row) but not in cells with satisfied abscission checkpoints (upper row) | View Abstract

  • Schematic model to explain how the squirrel monkey retroCHMP3 protein can potently inhibit HIV-1 budding while sparing host cytokinetic abscission

    Schematic model to explain how the squirrel monkey retroCHMP3 protein can potently inhibit HIV-1 budding while sparing host cytokinetic abscission | View Abstract

Welcome to the Sundquist Lab

We subscribe to the adage that “viruses are the window on the cell,” and believe that viruses have much to teach us about cell biology and biological principles. All of the projects in our lab had their origins in viral systems, although some have now evolved primarily into biochemistry, cell biology or synthetic biology. Specifically, we study the molecular and structural biology of retroviruses, with particular emphasis on the Human Immunodeficiency Virus (HIV).

Most importantly, we strive to create a rigorous, supportive, creative, fun, diverse, inclusive and equitable lab environment.